Moses Maseko was born in Daveyton east of Johannesburg in 1979.
After finishing school in 1996, Masoko worked with two friends doing sign writing on banners, billboards and printing T-shirts. In 1997, he created fabric designs at a place called Ezixelele Hlombe as well as at Vosloorus Art Centre. The next year he attended the Artist Pro Studio where he did print making for three years. This was a non-governmental organisation which helped black artists. While there, Masoko taught art at an informal school in Hillbrow, called the Creative Inner City Initiative (CICI).
In 2003, Masoko took his art to new frontiers by studying formally at the South African Printing College. His art works were exhibited at the Art on Paper Gallery in Melville and at many other galleries. He has also been featured in Dirkie Offringa’s book, Walking Tall, Without Fear, 24 South African Artist’s from the struggle era.